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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. Prednisone 10 mg orally daily is prescribed for a 68-year-old 60-kg patient with acute temporal arteritis. The pharmacotherapy specialist would recommend which of the following?

A) Dose should be decreased to 5 mg daily.
B) Dose should be increased to 20 mg daily.
C) Prednisone should be discontinued after 2 Weeks.
D) Dose should be increased to 60 mg daily.

2. Initial efficacy data on an experimental drug in the United States are usually collected in:

A) Phase trials.
B) Phase III trials.
C) Phase IV trials.
D) Phase trials.

3. Before initiating thrombolytic therapy in a 58 year old patient who has just sustained an acute anterior MI, which of the following must be ascertained?

A) Vital signs, current medications and cardiac enzymes
B) Medical history, vital sign, duration of chest pain, and current medications
C) aPTT, serum electrolytes and duration of chest pain
D) Medical history, current medications, and serum electrolytes

4. A pharmacotherapy specialist is conducting a pharmacokinetic study of a drug. The pharmacokinetic profile of this drug is best described by a one-compartment model with a mean elimination rate constant of 0.173/h. The standard curve for the assay to be used covers the range of 5-40mcg/mL. Samples are collected shortly after single intravenous bolus drug administration, and at 4 and 8 hours after dosing. Preliminary analysis shows that the 4-hour sample concentration is 25 mcg/mL. In this situation, which of the following statements is correct?

A) All plasma concentrations are probably within the range of the standard curve and can be reliably measured.
B) Both the initial and 8-hour concentration points are probably outside the range of the standard curve and cannot be reliably measured without diluting the samples.
C) The initial plasma concentration is probably outside the range of the standard curve' it may be possible to dilute the sample and re-assay.
D) Both the initial and 8-hour concentration points are probably outside the range of the standard curve but can be reliably quantitated by extrapolating the curve to higher and lower points.

5. A patient presents with palpitations and shortness of breath. A 12-lead ECG reveals a regular narrow QRS complex supraventricular tachycardia. What is the recommended first-line therapy?

A) Verapamil
B) Amiodarone
C) Adenosine
D) Lidocaine

Solutions: