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SASInstitute A00-282 Exam Syllabus Topics:

SectionObjectives
Topic 1: Clinical Trials Data Standards- CDISC Standards
  • 1. ADaM datasets and analysis-ready data
    • 2. SDTM structure and implementation
      Topic 2: Regulatory and Clinical Research Concepts- Clinical trial workflow
      • 1. Regulatory submission basics
        • 2. Study design fundamentals
          Topic 3: SAS Programming for Clinical Trials- Data Management
          • 1. Dataset merging and manipulation
            • 2. Data cleaning and transformation
              - Reporting and Analysis
              • 1. Statistical reporting with SAS procedures
                • 2. Listings, tables, and figures generation

                  SASInstitute Clinical Trials Programming Using SAS 9.4 Sample Questions:

                  1. The following SAS program is submitted:

                  You want to store all calculated means and standard deviations in one SAS data set.
                  Which statement must be added to the program?

                  A) output out=WORK.RESULTS mean=m1 m2 std=s1 s2;
                  B) ods output mean=m1 m2 std=s1 s2;
                  C) output mean std;
                  D) ods output out=WORK.RESULTS mean=m1 m2 std=s1 s2;


                  2. A dataset contains systolic blood pressure values stored in the variable SYSBP.
                  Which program displays the median systolic blood pressure over all participants?

                  A) proc freq data=vitals;
                  tables sysbp;
                  run;
                  B) proc means data=vitals;
                  var sysbp;
                  run;
                  C) proc summary data=vitals print;
                  var sysbp;
                  run;
                  D) proc univariate data=vitals;
                  var sysbp;
                  run;


                  3. Which statement correctly describes an aspect of a Phase II clinical trial?

                  A) designed to assess how well the drug works
                  B) designed to assess the pharmacovigilance, pharmacokinetics, and pharmacodynamics of a drug
                  C) randomized controlled multicenter trials on large patient groups
                  D) in vitro and in vivo experiments using wide-ranging doses of the drug


                  4. Given the following data set:

                  Which program was used to prepare the data for this PROC PRINT output?

                  A) proc sort data=one out=two nodup; by subjid; run;
                  B) proc sort data=one out=two nodupkey; by subjid; run;
                  C) proc sort data=one out=two; by subjid; run;
                  D) proc sort data=one out=two nodupkey; by subjid trt;


                  5. Study day is defined as DCMDATE minus RFSTDTC +1

                  Which statement will compute the study day correctly without producing notes for missing values in the log?

                  A) STUDYDAY=input(DCMDATE,yymmdd8.)-input(RFSTDTC,date9.)+1;
                  B) If RFSTDTC^='' and length(DCMDATE)=8 then STUDYDAY=input(DCMDATE,yymmdd8.)- input(RFSTDTC,date9.)+1;
                  C) STUDYDAY=DCMDATE-RFSTDTC+1;
                  D) If RFSTDTC^='' and length(DCMDATE)=8 then STUDYDAY=input(DCMDATE,date9.)- input(RFSTDTC,yymmdd8.)+1;


                  Solutions:

                  Question # 1
                  Answer: A
                  Question # 2
                  Answer: D
                  Question # 3
                  Answer: A
                  Question # 4
                  Answer: B
                  Question # 5
                  Answer: B

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